
The Def Pen Sports’ NFL Sunday Picks take a look at the best week one matchups.
Denver Broncos at New York Giants (+2.5)
At full health, the Giants’ offensive line was going to be a problem. Trading for 2 interior linemen in as many weeks lets us know the Giants don’t believe their line is entering the season healthy. Saquan Barkley has a chance to play week one but no one knows how much he will play. Expect Bradley Chubb and Von Miller to meet at the quarterback early and often. If the Giants are unable to create a push in the run game and consistently put Daniel Jones in 3rd and longs, things could get out of hand in a hurry. If Teddy Bridgewater protects the football, the Broncos could be starting the season with an easy, but not aesthetically pleasing, week one win on the road. At the moment, most of the public money is coming in on the Giants. This line will almost certainly get to (-3) or (-3.5) by kick-off.
PICK- Broncos -2.5
True to it. Not new to it. pic.twitter.com/OKRha4XCKY
— Houston Texans (@HoustonTexans) September 12, 2021
Houston Texans at Jacksonville Jaguars (-2.5)
If you believe the Texans have a chance to be historically bad this season, this might be the smallest spread you’ll see this season involving Houston. Urban Meyer and the Jaguars aren’t necessarily the poster boys of competence, but you may not get another chance to bet against the Texans for less than a field goal all season. This is a game where you place your bet and never watch a second of the game.
PICK- Jaguars

-2.5 Tennessee Titans at Arizona Cardinals (+3)
For years, the Cardinals struggled to find a cornerback that could play opposite Patrick Peterson. In 2021, Peterson is now in Minnesota and the Cardinals’ cornerback group looks like the worst unit in all of football. Enter AJ Brown and Julio Jones. The Titans should be able to pick the Cardinals apart with physical runs inside and play-action passes over the top.
PICK- Titans
Papi’s Home. pic.twitter.com/iC5POdE3Bc
— Detroit Lions (@Lions) September 12, 2021
-3 San Francisco 49ers at Detroit Lions (+7.5)
This 49ers’ defense teeing off against a porous Detroit offensive line is nightmare fuel for Lions fans. Despite what Detroit brass said after the Matthew Stafford trade, Jared Goff is not their quarterback of the future. His contract was the tax they paid for an additional first-round pick from the Rams. The Lions have no wide receiver depth and will struggle to score points. This is the start of what will be a very long season for the Lions.
PICK- 49ers

-7.5 UPSET PICK OF THE WEEK Pittsburgh Steelers at Buffalo Bills (-6.5)
Josh Allen was a completely different player in 2020 than he was at any other point in his career. It’s possible the leap was real but there will certainly be some statistical regression. Also, despite what their record would indicate, the Bills were in more one-score games than you think. On paper, the Bills should win handily but as we all know the first week of the NFL season is sure to be full of surprises. Big Ben lost some weight and has a new weapon in Najee Harris. Pittsburgh should be able to mitigate a disadvantage in the trenches by establishing the short passing game early and often.
PICK- Steelers +6.5
NFL Sunday Picks Week One: Get Rich Quick Parlay of the Week
Steelers ML +230/Dolphins ML +120/Washington Football Team ML +105 $100 Bet Pays out $1,388