Here is a list of the most significant NFL injuries in week five.

J.J. Watt – DE – Houston Texans

The heart and soul of this Houston Texans defense left the stadium in an ambulance on Sunday night. News broke that Watt suffered a tibial plateau fracture and he will be out indefinitely.

Texans announce that J.J. Watt has a tibial plateau fracture to his left leg.

— Adam Schefter (@AdamSchefter) October 9, 2017

Early this morning, J.J. Watt tweeted about his disappointment of this injury.

I can’t sugarcoat it, I am devastated.
All I want to do is be out there on that field for my teammates and this city.
I’m sorry.

— JJ Watt (@JJWatt) October 9, 2017

Odell Beckham Jr. – WR – New York Giants

The New York Giants lost four wide receivers to injury on Sunday in their matchup against the Los Angeles Chargers. Odell Beckham Jr. had five grabs for 97 yards and a touchdown at the time of his injury. He left in obvious pain.

This is so hard to watch. pic.twitter.com/DGZ82xQ3f9

— NFL Update (@MySportsUpdate) October 8, 2017

After an MRI on Sunday, the New York Giants told the media that OBJ suffered a fractured ankle.

Injury Update: wide receiver Odell Beckham Jr. has a fractured ankle.

— New York Giants (@Giants) October 8, 2017

Whitney Mercilus – LB – Houston Texans

Not only did the Texans lose J.J. Watt, they lost another premier pass rusher in Whitney Mercilus. He left the game after the opening drive due to a chest injury.

#Texans Whitney Mercilus has a torn pectoral and will be out for the year. Huge blow to maybe the most underrated pass rushers in the NFL.

— James Palmer (@JamesPalmerTV) October 9, 2017

Other Notable Injuries

Travis Kelce – TE – Kansas City Chiefs (Concussion)
Steven Terrell – S – Kansas City Chiefs (Concussion)
Chris Conley – WR – Kansas City Chiefs (Achilles)
Bilal Powell – RB – New York Jets (Calf)
Kevin King – CB – Green Bay Packers (Concussion)
Terrance West – RB– Baltimore Ravens (Calf)
Matt Skura – OG – Baltimore Ravens (Knee)
Chidobe Awuzie – CB – Dallas Cowboys (Hamstring)
Haloti Ngata – DT – Detroit Lions (Elbow)
Brandon Marshall – WR – New York Giants (Ankle)
Sterling Shepard – WR – New York Giants (Ankle)
Dwayne Harris – WR – New York Giants (Fractured Foot)
DeVante Parker – WR – Miami Dolphins (Ankle)
Taylor Lewan – OT – Tennessee Titans (Knee)
Lane Johnson – OT – Philadelphia Eagles (Concussion)
Charles Clay – TE – Buffalo Bills (Knee)
Leonard Johnson – CB – Buffalo Bills (Hamstring)
Aaron Brewer – LS – Arizona Cardinals (Broken Hand)
Tyler Boyd – WR – Cincinnati Bengals (Knee)
Adam Jones – CB – Cincinnati Bengals (Lower Back)
Dre Kirkpatrick – CB – Cincinnati Bengals (Shoulder)